Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies

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Documentation for package ‘dfped’ version 1.1

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dfped-package Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
albAge Concentration of albumin according to age.
alpha1AGage Concentration of alpha1-acid glycoprotein according to age.
Cladu Clearance of the unbound fraction of a specific molecule for the adult population.
Clch.Allo Paediatric clearance according to the allometry adjustment (AA) for a specific age.
Clch.Linear Paediatric clearance according to the linear adjustment (LA) for a specific age.
Clch.Mat Paediatric clearance according to the maturation adjustment (MA) for a specific age.
Clchu Clearance of the unbound fraction of a specific molecule for the paediatric population.
concAd Concentration of a specific molecule in plasma for the adult population.
concCh Concentration of a specific molecule in plasma for the paediatric population.
crmAtj A simulation of a single dose-finding trials in paediatrics.
dfped Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
doseChoice Choice of the next given dose level.
doseRange Dose-range for the paediatric population according to adult clearance, adult doses and paediatric clearance.
Fch Paediatric bioavailability according to age.
fitDataj Function for the Watanabe-Akaike information criteria (WAIC)
fuCh Unbound fraction of the molecule in the plasma for children.
KCYP1A2 Fraction of adult CYP1A2 abundance according to age.
KCYP2B6 Fraction of adult CYP2B6 abundance according to age.
KCYP2C18_19 Fraction of adult CYP2C18/CYP2C19 abundance according to age.
KCYP2C8 Fraction of adult CYP2C8 abundance according to age.
KCYP2C9 Fraction of adult CYP2C9 abundance according to age.
KCYP2D6 Fraction of adult CYP2D6 abundance according to age.
KCYP2E1 Fraction of adult CYP2E1 abundance according to age.
KCYP3A Fraction of adult CYP3A abundance according to age.
KCYP3A4_5 Fraction of adult CYP3A4/CYP3A5 abundance according to age.
kickoffControl Control for presence of at least toxicities and efficacies for the good run of bCRM model.
metaPhase Meta-analysis function of dose-finding studies proposed by Zohar et al, (2011).
plotEstimates Build a working model.
priorChoice Decision function for the choice of variance (sigmaHI or sigmaLI) in the adaptive prior variance calibration.
saveSimu Simulate one or "n" dose-finding trials in paediatrics.
sigmaEss The variance of the effective sample size (ESS).
sigmaHI Compute the informative prior variance for the adaptive prior.
sigmaLI Compute the least informative prior variance for the adaptive prior.
simu A simulation of a single dose-finding trials in paediatrics.
simulation Simulate one or "n" dose-finding trials in paediatrics.
skeleton Build a working model.
waic Function for the Watanabe-Akaike information criteria (WAIC)
weightCYPsum Proportion of the molecule metabolised by the CYPs for a child according to age.