Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Documentation for package ‘Phase12Compare’ version 1.5

AssignEffTox	Determines the optimal dose to assign the next patient cohort.
AssignEffToxUT	Determines the optimal dose to assign the next patient cohort.
GETBIN	Generate binary bivariate data.
GetDesire	Returns the desireability value of a dose.
GetEfftoxContour	Assigns next patient cohort based on the Efftox model with a Desirability based objective function.
GetEfftoxUt	Assigns next patient cohort based on the Efftox model with a Utility based objective function.
GetPriorsSPSO	Returns prior dose-specific means and prior ESS for the SPSO model.
GetSpsoContour	Assigns next patient cohort based on the SPSOP model with a Utility based objective function.
GetSpsoUt	Assigns next patient cohort based on the SPSOP model with a Utility based objective function.
ReturnOpt	Obtains optimal dose level.
RunAdaptiveEffToxTrialCORR	Simulates utility based Efftox trials
RunAdaptiveEffToxTrialCORRCONTOUR	Simulates desirability based Efftox trials
SimEfftoxContour	Simulates trial replications from the Efftox model with desirability optimality function.
SimEfftoxUt	Simulates trial replications from the Efftox model with utility optimality function.
SimSpsoContour	Simulates trial replications from the SPSO model with desirability optimality function.
SimSpsoUt	Simulates trial replications from the SPSO model with desirability optimality function.
UTEFFTOX	Samples from the posterior of the utility based phase12 model.